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41.
42.
Preparation and characterization of methoxy‐poly(ethylene glycol) side chain grafted onto chitosan as a wound dressing film 下载免费PDF全文
Cheng‐Han Yang Szu‐Hsien Chen Yun‐Wen Pan Ching‐Nan Chuang Wen‐Chi Chao Tai‐Horng Young Wen‐Yen Chiu Chih‐Kuang Wang Kuo‐Huang Hsieh 《应用聚合物科学杂志》2015,132(31)
Chitosan has received extensive attention as a biomedical material; however, the poor solubility of chitosan is the major limiting factor in its utilization. In this study, chitosan‐based biomaterials with improved aqueous solubility were synthesized. Two molecular weights (750 Da and 2000 Da) of methoxypoly(ethylene glycol) (mPEG) were grafted onto chitosan (mPEG‐g‐chitosan) to form a ~100‐μm‐thick plastic film as a wound dressing. The chemical structures of the mPEG‐g‐chitosan copolymers were confirmed using Fourier transform infrared spectroscopy (FTIR), and the thermal properties were characterized using thermogravimetry analysis (TGA). Their microstructures were observed using scanning electron microscopy (SEM). The other properties were analyzed via the swelling ratio, tensile strength, elongation, and water vapor transmission rate (WVTR). Biocompatibility evaluations through biodegradability, cytotoxicity, and antimicrobial effect studies were also performed. The obtained mPEG‐g‐chitosan copolymers were soluble in slightly acidic aqueous solutions (pH~6.5) at a concentration of 10 wt %. The optimal mPEG‐g‐chitosan hydrogels had swelling ratios greater than 100% and WVTRs greater than 2000 g/m2/day. Their performance against Staphylococcus aureus will be subjected to further improvements with respect to medical applications. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42340. 相似文献
43.
Jih-Jung Chen Chieh-Kai Yang Yueh-Hsiung Kuo Tsong-Long Hwang Wen-Lung Kuo Yun-Ping Lim Ping-Jyun Sung Tsung-Hsien Chang Ming-Jen Cheng 《International journal of molecular sciences》2015,16(5):9719-9731
Three new coumarin derivatives, 8-formylalloxanthoxyletin (1), avicennone (2), and (Z)-avicennone (3), have been isolated from the stem bark of Zanthoxylum avicennae (Z. avicennae), together with 15 known compounds (4–18). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4, 9, 12, and 15 exhibited inhibition (half maximal inhibitory concentration (IC50) values ≤7.65 µg/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 1, 2, 4, 8 and 9 inhibited fMLP/CB-induced elastase release with IC50 values ≤8.17 µg/mL. This investigation reveals bioactive isolates (especially 1, 2, 4, 8, 9, 12 and 15) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases. 相似文献
44.
Chien-Chang Lu Hsing-Chun Kuo Feng-Sheng Wang Ming-Huey Jou Ko-Chao Lee Jiin-Haur Chuang 《International journal of molecular sciences》2015,16(1):159-177
Toll-like receptors (TLRs) not only form an important part of the innate immune system but also serve to activate the adaptive immune system in response to cancer. Real-time PCR; immunohistochemical stain and Western blotting analyses were performed to clarify molecular alterations in colorectal cancer (CRC) patients. We identified Toll-like receptor 1 (TLR1), TLR2, TLR4 and TLR8 gene expression levels and downstream gene, i.e., interleukin-6 (IL-6), IL-8, interferon-α (IFN-α) and myeloid differentiation primary-response protein-88 (MyD88), expression levels in CRC patients and in cancer cell lines. CRC tissues have higher TLR1, TLR2, TLR4, TLR8, IL-6 and IL-8 gene expression levels than do the normal colon mucosa (p < 0.05). TLR2 expression varied in different cell types (mucosa and lymphocytes). There was no difference in the MyD88 and IFN-α gene expression levels between cancerous and normal colon mucosa. CRC patients had higher levels of IL-6 (p = 0.002) and IL-8 (p = 0.038) expression than healthy volunteers did; and higher IL-6 and IL-8 expression was also found to signify a higher risk of recurrence. CL075 (3M002) treatments can reduce the production of IL-8 in different cancer cell lines. The signaling pathway of TLRs in cancer tissue is different from that in normal cells; and is MyD88-independent. Higher expression levels of TLR1, TLR2, TLR 4 and TLR 8 mRNA were related to upregulation inflammatory cytokines IL-6 and IL-8 gene expression in tissue and to the upregulation of IL-6 in blood. The concentration of IL-6 in serum can be used as an indicator of the possibility of CRC recurrence. Treatment with 3M002 can reduce IL-6 production in vitro and may prevent CRC recurrence. Our findings provide evidence that TLR1, TLR2, TLR4 and TLR8 gene expression induce downstream IL-6 and IL-8 gene expression; detection of these expression levels can serve as a CRC marker. 相似文献
45.
Ying-Yu Kuo Wai-Tim Jim Liang-Cheng Su Chi-Jung Chung Ching-Yu Lin Chieh Huo Jen-Chih Tseng Shih-Han Huang Chih-Jen Lai Bo-Chih Chen Bi-Juan Wang Tzu-Min Chan Hui-Ping Lin Wun-Shaing Wayne Chang Chuang-Rung Chang Chih-Pin Chuu 《International journal of molecular sciences》2015,16(5):10748-10766
Head and neck cancers, which affect 650,000 people and cause 350,000 deaths per year, is the sixth leading cancer by cancer incidence and eighth by cancer-related death worldwide. Oral cancer is the most common type of head and neck cancer. More than 90% of oral cancers are oral and oropharyngeal squamous cell carcinoma (OSCC). The overall five-year survival rate of OSCC patients is approximately 63%, which is due to the low response rate to current therapeutic drugs. In this review we discuss the possibility of using caffeic acid phenethyl ester (CAPE) as an alternative treatment for oral cancer. CAPE is a strong antioxidant extracted from honeybee hive propolis. Recent studies indicate that CAPE treatment can effectively suppress the proliferation, survival, and metastasis of oral cancer cells. CAPE treatment inhibits Akt signaling, cell cycle regulatory proteins, NF-κB function, as well as activity of matrix metalloproteinase (MMPs), epidermal growth factor receptor (EGFR), and Cyclooxygenase-2 (COX-2). Therefore, CAPE treatment induces cell cycle arrest and apoptosis in oral cancer cells. According to the evidence that aberrations in the EGFR/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling, NF-κB function, COX-2 activity, and MMPs activity are frequently found in oral cancers, and that the phosphorylation of Akt, EGFR, and COX-2 correlates to oral cancer patient survival and clinical progression, we believe that CAPE treatment will be useful for treatment of advanced oral cancer patients. 相似文献
46.
The effect of manganese sulfide (MnS) inclusions on the machinability of free-cutting steel is based on their morphology, size and distribution. Furthermore, the plasticity of MnS is high during the hot working caused different characterization of MnS. In this study, the deformation behavior of MnS in 1215MS steel after a thermomechanical process was investigated at 1323 K. The microstructures of MnS inclusions were characterized by optical microscopy, scanning electron microscopy, energy-dispersive spectrometry, and electron backscattering diffraction (EBSD). As the thickness reduction of the inclusions increased from 10 to 70%, their average aspect ratio increased from 1.20 to 2.39. In addition, the deformability of MnS inclusions was lower than that of the matrix. The possible slip systems of A, B, C, and D plane traces were \(\left( {\bar{1}0\bar{1}} \right)\left[ {\bar{1}01} \right],\left( {10\bar{1}} \right)\left[ {101} \right],\left( {011} \right)\left[ {01\bar{1}} \right]\), and \(\left( {110} \right)\left[ {1\bar{1}0} \right]\). Furthermore, the EBSD measurements suggested that slip planes in MnS inclusions occur on {110} planes. 相似文献
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48.
In their original forms, carbon nanotubes (CNT) are spatially entangled. To make CNT papers (CNTPs), the CNT agglomerates must be dispersed and re‐entangled into a planar sheet. The processing characteristics are very different from those of traditional buck‐form nanocomposites. This article examines the processing, micro‐structures, and failure behavior of the CNTP composites. The CNTPs were first made by a dispersion and filtering process. Then, an epoxy resin was added into the CNTP by using a vacuum bag method. Different CNT weights were employed to make the CNTPs with different thicknesses and areal weights. The CNTP allows direct resin impregnation along the thickness direction and avoids the difficulty of dispersing CNTs in the viscous resin. The CNT content can be much higher than that attainable in traditional bulk CNT composites. Both tensile and tearing tests were conducted, and the fracture behaviors were examined. POLYM. COMPOS., 37:1564–1571, 2016. © 2014 Society of Plastics Engineers 相似文献
49.
Planar Heterojunction Perovskite Solar Cells Incorporating Metal–Organic Framework Nanocrystals 下载免费PDF全文
50.
Artificial Photosynthesis: Ni‐Nanocluster Modified Black TiO2 with Dual Active Sites for Selective Photocatalytic CO2 Reduction (Small 2/2018) 下载免费PDF全文